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pentobarbital will decrease the extent or outcome of netupitant/palonosetron by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Netupitant is mainly metabolized by CYP3A4; prevent use in clients who will be chronically applying a strong CYP3A4 inducerpentobarbital will minimize the level or outcome of fi